首页> 外文OA文献 >Augmented acetylcholine-induced, Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats

【2h】

Augmented acetylcholine-induced, Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats

机译：抗原诱导的气道高反应性大鼠中增强的乙酰胆碱诱导的，Rho介导的支气管平滑肌收缩的Ca2 +致敏

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

Treatment with acetylcholine (ACh) of a β-escin-permeabilized intrapulmonary bronchial smooth muscle of the rat induced force when the Ca2+ concentration was clamped at 1 μM. The ACh-induced Ca2+ sensitization of myofilaments was significantly greater in antigen-induced airway hyperresponsive rats than in control rats. The ACh-induced Ca2+ sensitization was completely blocked by treatment with Clostridium botulinum C3 exoenzyme, an inactivator of Rho family of proteins. Moreover, the protein level of RhoA in the intrapulmonary bronchi was significantly increased in the airway hyperresponsive rats. Thus, increased airway smooth muscle contractility observed in asthmatics may be related to augmented agonist-induced, Rho-mediated Ca2+ sensitization of myofilaments.

机译：当Ca2 +浓度固定在1μM时，用乙酰胆碱（ACh）处理大鼠的β-七叶桃通透性肺内支气管平滑肌。在抗原诱导的气道高反应性大鼠中，ACh诱导的肌丝Ca2 +敏化程度明显高于对照组。 ACh诱导的Ca2 +致敏作用可以通过肉毒梭状芽胞杆菌C3外切酶（一种Rho蛋白家族的失活剂）进行完全阻断。此外，在气道高反应性大鼠中，肺内支气管中RhoA的蛋白质水平显着增加。因此，在哮喘患者中观察到的气道平滑肌收缩力增加可能与激动剂诱导的，Rho介导的肌丝Ca2 +敏化增强有关。

著录项

作者
Chiba, Yoshihiko; Takada, Yuka; Miyamoto, Shigeki; Mitsui-Saito, Minori; Karaki, Hideaki; Misawa, Miwa;
展开▼
作者单位

展开▼
年度 1999
总页数
原文格式 PDF
正文语种 en
中图分类

相似文献

外文文献
中文文献
专利

1. SPecial report Augmented acetylcholine-induced, Rho-mediated Ca~2+ Sensitization of bronchial smooth muscle contraction in Antigen-induced airway hyperresponsive rats [J] . Yoshihiko Chiba, Yuka Takada, Shigeki Miyamoto British Journal of Pharmacology . 1999,第3期

机译：特别报告抗原诱导的气道高反应性大鼠增强乙酰胆碱诱导的，Rho介导的Ca〜2 +对支气管平滑肌收缩的敏感性
2. Enhanced Ca2+ sensitization of the bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats. [J] . Chiba Y, Sakai H, Suenaga H, Research communications in molecular pathology and pharmacology . 1999,第1a2期

机译：抗原诱导的气道高反应性大鼠中支气管平滑肌收缩的Ca2 +增敏作用。
3. Augmented acetylcholine-induced translocation of RhoA in bronchial smooth muscle from antigen-induced airway hyperresponsive rats [J] . Yoshihiko Chiba, Hiroyasu Sakai, Miwa Misawa British Journal of Pharmacology . 2001,第6期

机译：增强的乙酰胆碱诱导的抗原诱导的气道高反应性大鼠支气管平滑肌中RhoA的移位
4. Prediction of osmotic airway hyperresponsiveness in patients with bronchial asthma using adaptive neuro-fuzzy network [C] . Kolosov Victor P., Bezrukov Nikolay S., Naumov Denis Ye., 2015 International Conference on Biomedical Engineering and Computational Technologies . 2015

机译：自适应神经模糊网络预测支气管哮喘患者的渗透气道高反应性
5. Studies on the growth of smooth muscle from the airways of hyperresponsive rats. [D] . Zacour, Mary Eleanor. 1998

机译：高反应性大鼠气道平滑肌生长的研究。
6. Augmented acetylcholine-induced Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats [O] . Yoshihiko Chiba, Yuka Takada, Shigeki Miyamoto, 1999

机译：抗原诱导的气道高反应性大鼠中增强的乙酰胆碱诱导的Rho介导的支气管平滑肌收缩的Ca2 +敏化
7. Augmented acetylcholine-induced translocation of RhoA in bronchial smooth muscle from antigen-induced airway hyperresponsive rats [O] . Chiba, Yoshihiko, Sakai, Hiroyasu, Misawa, Miwa 2001

机译：增强的乙酰胆碱诱导的抗原诱导的气道高反应性大鼠支气管平滑肌中RhoA的移位

Augmented acetylcholine-induced, Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats

摘要

著录项

相似文献

相关主题

期刊订阅